In elderly patients, what factor may cause adverse events related to medication use?

In elderly patients, increased sensitivity to medications is a significant factor that can lead to adverse events. As people age, their bodies undergo various physiological changes that can affect the pharmacodynamics—how the body responds to drugs. This can manifest as heightened sensitivity to certain medications, especially central nervous system agents, which can lead to increased risks for side effects and complications.

Elderly individuals may experience altered drug metabolism and excretion, often due to changes in organ function, including liver and kidney function. This makes them susceptible to both therapeutic and adverse effects at doses that might be well-tolerated in younger populations. Therefore, recognizing that elderly patients may react differently to drugs underscores the importance of careful medication management, including dosage adjustments and ongoing monitoring for side effects.

This understanding informs the practice of Medication Therapy Management (MTM), emphasizing the need for individualized approaches to treatment in the elderly to minimize the risk of adverse drug reactions resulting from increased sensitivity.